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Clinical Trials

Clinical Trials on Ginseng

Panax ginseng: a systematic review of adverse effects and drug interactions.
JT Coon, E Ernst

Panax ginseng C. A. Meyer is a perennial herb native to Korea and China and has been used as an herbal remedy in eastern Asia for thousands of years. Modern therapeutic claims refer to vitality, immune function, cancer, cardiovascular diseases, improvement of cognitive and physical performance and sexual function.

This review was conducted as a systematic attempt to document and evaluate all the available safety data on P. ginseng root extracts. Systematic searches were performed in five electronic databases and the reference lists of all papers located were checked for further relevant publications.

All articles containing original data on adverse events and drug interactions with P. ginseng were included. Information was also requested from 12 manufacturers of ginseng preparations, the spontaneous reporting schemes of the WHO and national drug safety bodies. No language restrictions were imposed.

Data from clinical trials suggest that the incidence of adverse events with ginseng monopreparations is similar to that with placebo. The most commonly experienced adverse events are headache, sleep and gastrointestinal disorders. The possibility of more serious adverse events is indicated in isolated case reports and data from spontaneous reporting schemes; however, causality is often difficult to determine from the evidence provided. Combination products containing ginseng as one of several constituents have been associated with serious adverse events and even fatalities. Interpretation of these cases is difficult as ingredients other than P. ginseng may have caused the problems.

Possible drug interactions have been reported between P. ginseng and warfarin, phenelzine and alcohol. Collectively, these data suggest that P. ginseng monopreparations are rarely associated with adverse events or drug interactions. The ones that are documented are usually mild and transient. Combined preparations are more often associated with such events but causal attribution is usually not possible

Source http://adisonline.com/drugsafety/pages/articleviewer.aspx?year=2002&issue=25050&article=00003&type=abstract

1,000’s of clinical studies show actual benefits:

Vitality
Energy
Mental Clarity
Joint Comfort
Blood quality
Detoxification
Anti Oxidant
PH Balance

Ginseng brings your body into balance

Since 1970 a great number of scientific studies have been done on Ginseng. There continues to be more and more discoveries and studies done every year. To learn more we suggest that you look at the website links shown at the bottom of this page.

What is Ginseng

Panax ginseng C. A. Meyer has been used for more than 2,000 years in the Orient. Ginseng is one of the most well-known and valued herbs in Korea, China, and Japan and it is one of the 12 medicinal herbs commonly used in America. Since the late 1960s, many studies have been performed to identify the active ingredients of ginseng and their functions. Clinical studies are still being performed every year adding to the strong scientific evidence of effectiveness of Ginseng for a broad range of health issues. Ginseng is considered an adaptogenic agent which enhances physical performance, promotes vitality, and increases resistance to stress and aging and possesses immunomodulatory activity. The adaptogenic properties of ginseng are believed to be due in part to its effects on the hypothalamic-pituitary-adrenal axis

In Chinese medicine, ginseng (Panax ginseng C.A. Meyer) has long been used as a general tonic or an adaptogen to promote longevity and enhance bodily functions. It has also been claimed to be effective in combating stress, fatigue, oxidants, and other serious conditions. Most of the pharmacological actions of ginseng are attributed to one type of its constituents, namely the ginsenosides.

Background and History

Ginseng, Panax ginseng C.A. Meyer, a precious Chinese traditional medicinal herb, has been known clinically used in China for thousands of years. The genus name ‘Panax’ was derived from Greek. ‘Pan’ means ‘all’ and ‘axos’ means ‘cure’. Literally ‘Panax’ can be translated as ‘cure-all’ or panacea. The herbal root is named ginseng because it is shaped like a man. Actually the term ‘ginseng’ represents two Chinese ideograms: ‘gin’ (pronounced ren) refers to ‘man’ and ‘seng’ (pronounced shen) refers to ‘essence’ It is believed to embody man’s three mythical essences – body, mind and spirit. Thus it is also referred to as the lord or king of herbs. Its medicinal efficacy was first documented inShengnong Bencao Jing and it was later summarized by Li Shizhen in Bencao Gangmu and Zhongyao Zhi (Chinese Materia Medica) by People’s Health Publishing House, Beijing, published in 1596 and 1959 respectively.

In the 18th century, the effectiveness of ginseng was recognized in the West, and subsequently, a large number of investigations were conducted on its botany, chemistry, pharmacology and therapeutic applications. Ginseng has been used as a general tonic or adaptogen for promoting longevity especially in the Far East, especially China, Korea and Japan.

Ginseng is a deciduous perennial plant that belongs to the Araliaceae family. Currently, twelve species have been identified in the genus Panax. Among them, Panax ginseng C. A. Meyer (Araliaceae), cultivated in China, Korea, Japan, Russia, and the US, P. quinquefolium L (American ginseng), grown in southern Canada and the US and P. notoginseng, cultivated in Yunnan and Guangxi provinces in China, represent the three most extensively investigated species.

Most studies claimed that the pharmacological effects of ginseng are attributed to its bioactive constituents such as ginsenosides, saponins, phytosterols, peptides, polysaccharides, fatty acids, polyacetylenes, vitamins and minerals

Angiogenesis in the human body is regulated by two sets of counteracting factors, angiogenic stimulators and inhibitors. Ilhwa Korean Ginseng Extract Concentrate has the broadest range of Ginsenosides and other bio acitive ingredients having both a ‘Yin and Yang’ action on the body.

The ‘Yin and Yang’ action of ginseng on angiomodulation was paralleled by the experimental data showing angiogenesis was indeed related to the compositional ratio between ginsenosides Rg1 and

Rb1. Rg1 and it was later found to stimulate angiogenesis through augmenting the production of nitric oxide (NO) and vascular endothelial growth factor (VEGF). Mechanistic studies revealed that such responses were mediated through the PI3K→Akt pathway. By means of DNA microarray, a group of genes related to cell adhesion, migration and cytoskeleton were found to be up-regulated in endothelial cells.

These gene products may interact in a hierarchical cascade pattern to modulate cell architectural dynamics which is concomitant to the observed phenomena in angiogenesis.

If you would like to research more about this remarkable herb Ginseng and to learn about the many clinical studies that have been done investigating the remarkable positive affect on our bodies please go the following websites:

www.ginsengtruth.com

National Institive on Health: National Center for Biotechnology Ginseng Research

Clinical Trials.gov/Ginseng

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